Crystal Structure of Biotin Carboxylase in Complex with Substrates and Implications for Its Catalytic Mechanism
نویسندگان
چکیده
منابع مشابه
Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism.
Biotin-dependent carboxylases are widely distributed in nature and have important functions in many cellular processes. These enzymes share a conserved biotin carboxylase (BC) component, which catalyzes the ATP-dependent carboxylation of biotin using bicarbonate as the donor. Despite the availability of a large amount of biochemical and structural information on BC, the molecular basis for its ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m805783200